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Product details

2-(3,4-DIHYDROXYPHENYL)-5 Luteolin CAS: 491-70-3

CAS: 491-70-3

Formula: C15h10o6

Molecular weight: 286.23

Density: 1.654 g/cm3

Melting point: 330 ° C

Boiling point: 616.1 ° C - 760 mmHg flash

Point: 239.5 ° C

Physical properties: yellow acicular crystal, Melting Point 328-330 ° C. Slightly soluble in water, slightly acidic, soluble in alkaline solution, stable under normal conditions.

Luteolin is a Natural Extracts flavonoid found in a variety of Plant P.E. Luteolin, in the form of glycosides, is found in a variety of plants. Food Additive has high content of whole-leaf cymbidium, capsicum, chrysanthemum, honeysuckle, perilla. Has the antitussive and expectorant effect. According to the latest research, respiratory symptoms cough,expectoration, wheezing, are associated with chronic airway inflammation. Such as asthma,chronic obstructive pulmonary disease, chronic pharyngitis, allergic rhinitis, etc. ,

Luteolin Jpg

causing cough, expectoration, wheezing, Natural Food Healthy Product are considered to be related to the local inflammatory infiltration, the presence of inflammation, the airway immune response is confused, and patients often have increased airway responsiveness. Treatment should begin by eliminating the chronic inflammatory infiltration of the airway. Currently, glucocorticoid is commonly used to reduce airway inflammation. However, glucocorticoid has more side effects and is not suitable for long-term use. Studies have shown that luteolin inhibits macrophage phosphorylation, inhibits the activity of the transcription factor NF-kB, and is able to inhibit lipopolysaccharide (LPS)-induced macrophage production of the cytokines IL-6, TNF-A. The latter two cytokines play a very important role in the inflammatory mechanism and are sensitive indicators to reflect the degree of inflammation. Luteolin also increases IFN-γ, decreases specific Ig-E, and reduces eosinophil granulocyteinfiltration. Besides its anti-inflammatory and anti-allergic effects, luteolin also has anti-PDE, anti-SARS and anti-HIV properties, to prevent it from entering the host cell.Anti-wrinkle material is used to treat chronic cough caused by COPD, asthma, chronic pharyngitis and allergic rhinitis.

Pharmacological activities:

1, anti-inflammatory: the anti-inflammatory activity of luteolin is thought to be related to the inhibition of protein tyrosine phosphorylation and nuclear factor KB (NF-KB)-mediated gene expression.

2.Antitumor: studies have shown that luteolin can selectively inhibit Fatty acid synthesis activity in prostate and breast cancer cells,

3.anti-allergic:-luteolin inhibits immunoglobulin E (IgE)-mediated allergic transmitter production by human mast cells anti-inflammatory

4.demyelinating diseases: luteolin protects oligodendrocyte against hydrogen peroxide-induced oxidative damage in a dose-dependent manner in vitro, strong inhibition of phagocytosis of myelin sheaths by macrophages significantly reduces the production of reactive oxygen species,

5.Anti-fibrosis: luteolin can reduce the degree of liver fibrosis, reduction of hydroxyproline (Hyp) , malondialdehyde (MDA) and expression of type I procollagen mRNA in liver tissue could inhibit proliferation and collagen synthesis of hepatic stellate cells(HSC) in vitro.

6. Anti-fertility and hormonal effects: luteolin has a significant dose-dependent anti-implantation activity. After oral administration, luteolin can significantly increase the weight, diameter, thickness of endometrium and the height of its epithelial cells, Health ingredient has estrogenic effect when used alone, but shows anti-estrogenic effect when used with ethinylestradiol. In vivo, luteolin inhibits the Vascular endothelial growth factor of VEGF-induced corneal angiogenesis in rabbits, and inhibits tumor growth and angiogenesis in a murine xenograft tumor model Vegf-induced survival and proliferation of human umbilical vein Endothelium (HUVECs) can be inhibited in vitro. Other luteolin can inhibit a variety

of bacteria and viruses, such as Staphylococcus aureus, E. coli, Human herpesvirus 1,poliovirus, coxsackievirus B3, etc. . Luteolin also has the role of immune regulation.