Spermidine is a polyamine compound that is widely present in living organisms. 1.Chemical Properties Basicity Spermidine is an organic base with multiple amino groups in its molecular structure. These amino groups can accept protons under physiological, giving spermidine a positive charge. This basic characteristic allows it to interact with negatively charged biomolecules such as DNA, RNA, and acidic phospholip. Solubility Spermidine is highly soluble in water and lower alcohols, which are polar solvents. This good solubility enables to function effectively in both intracellular and extracellular environments within living organisms. Additionally, its solubility in some organic solvents facilitates its use in chemical and research.

2. Sources Biological Synthesis In living organisms, spermidine is primarily synthesized through enzymatic reactions. Starting with arginine, a of metabolic steps, including decarboxylation and aminopropyl transfer reactions, ultimately produce spermidine. This process involves various enzymes and may differ among different organisms. Food Sources Many foods contain spermidine, such as wheat germ, soybeans, and mushrooms. The spermidine content in these can vary due to factors like variety and growing conditions. Consuming these spermidine-rich foods can provide the human body with a certain amount of spermidineIII. Uses and Applications Medical Field Anti-aging effects:
Spermidine has significant anti-aging properties. It can induce autophagy, self-cleaning mechanism within cells that removes damaged organelles and protein aggregates. By promoting autophagy, spermidine helps maintain cellular health and delays the process. In some animal studies, mice supplemented with spermidine have shown longer lifespans and improved health, such as enhanced heart function and cognitive abilities.
uroprotection:
Spermidine also has protective effects on the nervous system. It can reduce neuroinflammation and may have potential therapeutic value for neurogenerative diseases like Alzheimer's and Parkinson's. Research has found that spermidine can decrease oxidative stress and inflammatory responses in neurons, inhibiting neuronal apoptosis and protecting the integrity of the nervous system. Cardiovascular
protection:
In terms of cardiovascular health, spermidine can protect vascular endothelial cells and improve vascular function It can inhibit the proliferation of vascular smooth muscle cells, reducing the risk of atherosclerosis. Additionally, spermidine can regulate blood pressure, lowering the blood of hypertensive patients, and providing comprehensive protection for the cardiovascular system. Cosmetics Field
Skincare benefits:
Due to its antioxidant and autophagy-promoting, spermidine is used in cosmetics. It can be added to skincare products like creams and serums to improve skin texture and appearance. Spermidine reduce oxidative damage to skin cells, enhance skin elasticity, and decrease the formation of wrinkles, resulting in firmer and smoother skin. Agricultural Field Plant regulator: Spermidine can be used as a plant growth regulator in agriculture. It can promote seed germination and seedling growth, and enhance the plant resistance to adverse conditions such as drought, cold, and salt. Under drought conditions
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