Pharmacological effects of Adapalene？

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Adapalene is a retinoic acid compound that has been shown to have anti-inflammatory properties in in vivo and in vitro models of inflammation, is chemically stable, and is not easily decomposed by air and light. The mechanism of action is the same as that of retinoic acid, which can bind to specific retinoic acid nuclear receptors, the difference is that adapalene does not bind to cytoplasmic receptors that bind to proteins. Adapalene has been shown to treat acne in an animal model established in mice in a dermal drug test, and also has an effect on acne vulgaris and differentiation processes. The mechanism of action is to reduce the formation of microcomedones by normalizing the differentiation of Chemicalbook hair cells on the hair follicles. in standard anti-inflammatory assays in vivo and in vitro. Adapalene is more effective than retinoic acid, it can inhibit the chemotactic reaction of human polynuclear leukocytes, and can inhibit the metabolism of polymorphonuclear phylum by inhibiting the transformation of arachidonic acid into inflammatory mediators through lipid oxidation. , thereby alleviating inflammatory responses mediated by cellular responses. For the treatment of vulgar cutaneous acne characterized by pimples, papules and pustules. It can also be used to treat acne on the face, chest and back.

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